Parteneri

Mereuţă Loredana - Cristina

Universitatea ,,Alexandru Ioan Cuza" din Iaşi alt

Domeniul:

  • D1- matematica, fizica, chimie
  • D2- stiinte ale informatiei

E-mail: JLIB_HTML_CLOAKING

Vezi aici raportul de cercetare.

 

Present employment / position

  • Post-doctoral Fellow  POSDRU/89/1.5/S/63663 -grant "Trans-national network of integrated management for post-doctoral research in the field of Science Communication. Institutional construction (post-doctoral school) and fellowship Programme (CommScie)"

 

Work experience

  • 2007 -present -   Teaching assistant at ‘Alexandru I. Cuza’ University, Faculty of Physics, Department of Physics -   Laboratory, seminars and research activity with undergraduated students or master students

   

Education and training

  • 2007-2010 -  Doctoral Studies in Biophysics (distinction: summa cum laude)- Modulation of membrane activity of certain antimicrobial peptides and porins by electric and mechanic  properties of  the lipid matrix,    “Alexandru Ioan Cuza University, Faculty of Physics, Laboratory of Molecular Biophysics and Medical Physics;
  • 2005 – 2007 -  Master degree -  Master program of Biophysics and Medical Physics,   “Alexandru Ioan Cuza University, Faculty of Physics, Laboratory of Molecular Biophysics and Medical Physics
  • 2001-2005 -   Bachelor degree -  Bachelor program of Medical Physics,  “Alexandru Ioan Cuza’ University, Faculty of Physics.

 

Professional skills and competences

Work experience in the field of molecular and cellular biophysics:

  • electrophysiology
  • virtual instrumentation biophysics of artificial lipid membranes
  • extracellular recordings in excitable tissues
  • single-channel recording and analysis
  • antimicrobial and cell-penetrating peptides

 

Organisational skills and competences

  • Team work and scientific research experience acquired as member in 4 grants

 

Teaching activities

  • General biophysics  (B.Sc. students)
  • Modeling of Biological Processes (B. Sc. Students)
  • Systems biophysics (M.Sc. students)
  • Electromagnetic field action on complex systems (M.Sc. students)
  • Biocompatibility and biomaterials (M.Sc. students)
  • Neurotransmitters and neuro-pharmaceuticals (M.Sc. students)
  • Biomechanics (M.Sc. students)
  • Bioelectricity. Fundamentals and clinical applications (M.Sc. students)

 

Scientific research activity


  Areas of research Molecular and cellular biophysics

  •   11 ISI papers (10 article types)   11.4  personal ISI points
  •    h-index 4,              23 citations(without self-citations)
  •    30 communications presented at international and national conferences
  • November 2010 EBSA (European Biophysical Societies' Association) Bursary for attendance at ESF-EMBO Symposium Molecular Perspectives on Protein-Protein Interactions  –    Spain

Affiliation

  • Member of the Romanian Society of Pure and Applied Biophysics

 

List of selected journal papers, books, research grant

PAPERS IN ISI-QUOTED JOURNALS

  • Loredana Mereuta, Alina Asandei and Tudor Luchian, ‘Meet me on the other side: trans-bilayer modulation of a model voltage-gated ion channel activity by membrane electrostatics asymmetry’, PLoS ONE, 2011 6(9): e25276. doi:10.1371/journal.pone.0025276
  • Alina Asandei, Loredana Mereuta and Tudor Luchian, ‘The kinetics of ampicillin complexation by -cyclodextrins. A single molecule approach’, Journal of Physical Chemistry B  J. Phys. Chem. B, 2011, 115 (33), pp 10173–10181, DOI: 10.1021/jp204640t
  • Aurelia Apetrei, Loredana Mereuţă, Tudor Luchian The RH 421 styryl dye induced, pore model-dependent modulation of antimicrobial peptides activity în reconstituted planar membranes, Biochimica et Biophysica Acta (BBA) - General Subjects 1790 (8), 2009, 809-816 
  • Loredana Mereuţă, Tudor Luchian, Yoonkynung Park and Kyung-Soo Hahm, The role played by lipids unsaturation upon the membrane interaction of the Helicobacter pylori HP(2–20) antimicrobial peptide analogue HPA3, Journal of Bioenergetics and Biomembranes 41, 2009, 79–84
  • Loredana Mereuţă, Roxana Chiriac, Tudor Luchian, Activity modulation of certain ion-pore forming proteins by electric properties of artificial lipid membranes, Journal of Optoelectronic and Advanced Materials 10 (7), 2008,1837 – 1842
  • Alina Asandei, Loredana Mereuţă, Tudor Luchian, -‘Influence of membrane potenţials upon reversible protonation of acidic residues from the OmpF eyelet’, Biophysical Chemistry 135, 2008, 32–40
  • Loredana Mereuţă, Tudor Luchian, Yoonkyung Park and Kyung-Soo Hahm, Single-molecule investigation of the interactions between reconstituted planar lipid membranes and an analogue of the HP(2–20) antimicrobial peptide, Biochemical and Biophysical Research Communications 373 (4), 2008, 467-472
  • Tudor Luchian, Loredana Mereuţă, Selective transfer of energy through an alamethicin-doped artificial lipid membrane studied at discrete molecular level, Bioelectrochemistry 69, 2006, 94-98
  • Loredana Mereuţă, Tudor Luchian, A virtual instrumentation based protocol for the automated implementation of the inner field compensation method, Central European Journal of Physics 4(3), 2006, 405-416 
  • Tudor Luchian, Loredana Mereuţă, Phlorizin- and  6-ketocholestanol-mediated antagonistic modulation of alamethicin activity în phospholipid planar membranes, Langmuir 22(20), 2006, 8452-8457
  • Loredana Mereuţă, Tudor Luchian  How could a chirp be more effective than a louder clock – resonant transfer of energy between sub-threshold excitation pulses and excitable tissues, Journal of Cellular and Molecular Medicine 9(2), 2005, 446-456


RESEARCH GRANTS
as team member

  • 2008-2011 “Elucidation of mechanisms of interaction of selected cytotoxic peptides with tumor cells, and optimization of anti-tumoral properties of such peptides”, PN II nr. 62061/2008
  • 2007-2010 ‘Molecular characterization of antimicrobial peptides action mechanisms and de-novo prediction of molecular structures with enhanced antimicrobial potential’ PN II nr.61-016/2007
  • 2006-2008 ‘Nano-scale approach towards studying couplings between biomembranes, bacterial toxins and proteins with roles in drugs penetration’ 2-Cex 06-11-49 / 2006
  • 2006-2008 ‘Study of impermeability-mediated antimicrobial resistance mechanisms of Gram-negative bacteria in natural and reconstituted membranes’ CEEX nr.168/2006

 

Additional information